Article: Electrophysiological changes of CA3 neurons and dentate granule cells following transient forebrain ischemia.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Howard EM; Gao TM; Pulsinelli WA; Xu ZC Brain Res., 1998
Table 2Electrophysiological properties of DG neurons before and after ischemia
RMP: resting membrane potential.n: number of cells.Values are means±S.D.aANOVA P<0.01.bANOVA P<0.05.Spike height is measured from the resting membrane potential.Spike width is measured at 50% of the action potential amplitude.Input resistance is derived from the linear portion of the I–V curve (0∼−5 nA).Time constant is derived from transients of hyperpolarizing pulses (−0.3 nA, 200 ms).
Repefusion | RMP (mV) | Spike Height (mV) | Spike width (ms) | Input resistance (MΩ) | Time constant (ms) | Spontaneous firing (spike/s) |
Before | −75.58±6.58 (n=19) | 83.4±9.61 (n=19) | 0.834±0.138 (n=19) | 31.63±10.46 (n=15) | 9.32±5.79 (n=13) | 0.131±0.186 (n=18) |
∼2.0 h after | −69.9±4.57a (n=13) | 75.5±6.48 (n=13)b | 0.892±0.241 (n=13) | 29.15±4.72 (n=11) | 10.41±5.95 (n=11) | 0.023±0.070 (n=13) |
∼4.5 h after | −72.5±5.89 (n=15) | 79.6±9.95 (n=15) | 0.821±0.112 (n=15) | 32.35±9.10 (n=12) | 10.86±5.93 (n=12) | 0.143±0.224 (n=15) |
∼7.5 h after | −76.2±2.44 (n=9) | 83.7±8.77 (n=9) | 0.808±0.143 (n=9) | 32.81±7.86 (n=8) | 10.98±4.11 (n=8) | 0.011±0.033 (n=9) |
∼11 h after | −72.4±4.32 (n=12) | 79.5±6.57 (n=12) | 0.807±0.106 (n=12) | 36.57±17.08 (n=9) | 9.17±4.56 (n=9) | 0.00±0.00b (n=11) |